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The available engine options for the Yukon are:
- 8-395 (6.5L, turbo diesel, VIN S)
- 6.5L (turbo diesel, VIN S)
- 6.5L (turbo diesel, VIN S) 25 mm oil cooler line nut
- 6.5L (turbo diesel, VIN S) 32 mm oil cooler line nut
- (8-350, 5.7L, VIN "K")
- 8-350 (5.7L, VIN "K")
- 6.2L ( VIN 8, 8th digit, opt L92)
- 5.3L (VIN T, 8th digit)
- 5.3L (VIN T or VIN Z, 8th digit)
- 6.2L ( VIN 2, 8th digit, opt L9H)
- 4.8L (VIN V, 8th digit)
- 4.8L (VIN C, 8th digit, opt LY2)
- 6.0L (VIN U, 8th digit)
- 6.2L (VIN F, 8th digit, opt L94)
- 5.7L (VIN R, 8-350)
- (5.7L, VIN R, 8-350)
- 5.7L (VIN R, 8th digit)
- 5.3L VIN 0, 8th digit, opt LMG
- 5.3L VIN 0 (8th digit, opt LMG)
- 5.3L VIN J, 8th digit, opt LY5
- 5.3L VIN J (8th digit, opt LY5)
- 5.3L VIN 3 (8th digit, opt LC9)
- 5.3L (VIN 0, 8th digit, opt LMG)
- 6.0L (VIN 5, 8th digit, opt LFA, Hybrid)
- 6.0L (VIN J, 8th digit, opt LZ1, Hybrid)

